The Light Microscopic Study of Effect of Exposure and Withdrawal of Pyrethroid and Herbal Based Mosquito Vaporizers On the Kidney of Male Wistar Albino Rat

Background: Pyrethroids, organochlorines, organophosphates, and carbamates constitute important active ingredients of available mosquito repellents in the Indian market, in which pyrethroids are found very effective and safe. The natural compounds produced by plants can interfere major metabolic pathways, thus causing death of the insects. The aim of present study was to know the effect of exposure and withdrawal of transfluthrin and herbal based mosquito vaporizers on kidney of male albino rats. Material and Methods: We have taken kidney of 26 well preserved male albino wistar rats and divided in to three groups. Control group: Six rats; not exposed to any mosquito repellents. Experimental group 1- 12 rats: divided in subgroup 1A, the pyrethroid Exposure group; and subgroup 1B, the Pyrethroid withdrawal group. Experimental Group 2 – Eight rats: divided in subgroup 2A, the herbal Exposure group and 2B, the herbal withdrawal group. Results: The kidney of pyrethroid vaporizer exposed group showed gross changes in their histology than the herbal based mosquito vaporizer exposure group. Also, some of the normal histological features were recovered after withdrawal of chemicals and reversal was better in herbal based mosquito vaporizer. Conclusion: Histological findings of present study suggests that pyrethroid (Transfluthrin) based mosquito repellents are harmful to the kidney. Herbal based mosquito repellent also showed damage though the severity was mild as compared to pyrethroid. Reversal changes were much better in herbal withdrawal group than the pyrethroid withdrawal group.

Keywords: Pyrethroid, Transfluthrin, Herbal, Mosquito repellent, Kidney, Withdrawal.