A Study of Clinical, Radiological and Spirometric Profile in Post-Pulmonary Tuberculosis Patients in Tertiary Care Center of Western U.P

Arpit Goel, Mazher Maqusood, Pradeep Nirala, Abhishek Kumar, Chinmay Jethi, Rajul Rastogi, Chayan Chaplot, Manisha Rajak, Hemax Gandhi
Author(s)
1Resident, Department of Respiratory Medicine, Teerthanker Mahaveer Medical College & Research Centre, Delhi Road, Moradabad, Uttar Pradesh, India. 2Professor & HOD, Department of Respiratory Medicine, Teerthanker Mahaveer Medical College & Research Centre, Delhi Road, Moradabad, Uttar Pradesh, India. 3Professor, Department of Respiratory Medicine, Teerthanker Mahaveer Medical College & Research Centre, Delhi Road, Moradabad, Uttar Pradesh, India. 4Associate Professor, Department of Respiratory Medicine, Teerthanker Mahaveer Medical College & Research Centre, Delhi Road, Moradabad, Uttar Pradesh, India. 5Assistant Professor, Department of Respiratory Medicine, Teerthanker Mahaveer Medical College & Research Centre, Delhi Road, Moradabad, Uttar Pradesh, India. 6Professor, Department of Radiology, Teerthanker Mahaveer Medical College & Research Centre, Delhi Road, Moradabad, Uttar Pradesh, India

Abstract

Background: Pulmonary tuberculosis (PTB) causes variations in the pulmonary parenchyma. Considerable symptoms, radiographic issues, spirometry abnormalities, and a reduced quality of life are present in cases with post-TB patients. For correct diagnosis and treatment of COPD, a comprehensive understanding of clinical, radiological, and spirometric data is essential. Therefore, more recent research on this subject is always needed in nations like India where tuberculosis is highly prevalent. Thus the present study was done assessing clinical-radiological and spirometric profile in post-pulmonary TB cases in tertiary care center of Western Uttar Pradesh. Material and Methods: Present cross-sectional study was conducted on 163 patients aged 18 yrs and above who have completed anti-tuberculosis treatment. Clinical history, sputum examination (AFB/CBNAAT), Chest x-ray, spirometry evaluation, severity of airflow limitation were assessed. Data was evaluated using statistical analysis with SPSS version 20.0 software (IBM Chicago). Results: Right and upper zone (38%) was most commonly affected. 52.8% cases had Degree 2 involvement, with 63.2% cases with reduced DLCO. A significant relation (p<0.05) was seen between CXR degree of involvement with mMRC grading; between post-TB period with mMRC grading; between PFT abnormalities with degree of involvement; between mean post-TB period with FEV1%; mean pack years of smoking with airflow obstruction. Conclusion: Since post-TB can occur at any point during or following TB treatment, it is crucial to provide PTB patients with appropriate counseling and to follow up with them on a regular basis even after anti-TB therapy is finished. To identify lung damage early in its progression, regular spirometry may be helpful. In order to reduce post-TB fibrosis, early identification and adequate treatment of PTB are crucial.

Keywords: Spirometry; Tuberculosis; Pulmonary; Radiology.

Outline