Study the Clinical Profile of Acute Hepatic Dysfunction in Patients admitted in Intensive Care Unit

Background: To study the clinical profile of acute hepatic dysfunction in patients admitted in Intensive Care Unit. To study the outcome of patients with acute hepatic dysfunction in ICU in terms of Death and Discharge or Transfer out. Material and Methods: This study will evaluate the performance of Child-Turcotte-Pugh & MELD scores with the outcome of Acute Hepatic Dysfunction in critically ill patients. Approval from the Institution Ethics Committee of a tertiary care centre and teaching hospital was taken for cross sectional observational study of 50 cases developing ALF in ICU. Duration of study was from November 2017 to October 2019. Results: The age group having maximum deaths was 21-30 years (47.82%), with a female preponderance. The most common etiologies of ALF were Septic shock, Pregnancy associated Liver Complications, Zinc Phosphide associated FHF and Congestive Cardiac Failure. Morbidity and mortality due to pregnancy related liver diseases and zinc phosphide associated FHF can be prevented with early diagnosis and timely interventions. The role of General Examination and Systemic Examination of patients in predicting mortality is indispensable, with special emphasis on pallor, respiratory rate, presence of ascites and neurological assessment. Conclusion: The age group having maximum deaths was 21-30 years (47.82%), The most common etiologies of ALF were Septic shock. The role of General Examination and Systemic Examination of patients in predicting mortality is indispensable, with special emphasis on pallor, respiratory rate, presence of ascites and neurological assessment.

Keywords: Clinical profile, Acute Hepatic Dysfunction, Intensive Care Unit.