Large Scrotal Verruciform Xanthoma (VEGAS Xanthoma): A Case Report

Harshita Srivastava, Kritika Singh, Ketki Wajpeyi, Shreya Pandey
Author(s)
1Junior Resident, Department of Pathology, D.Y. Patil School of Medicine, Navi Mumbai, Maharashtra, India. 2Associate Professor, Department of Pathology, D.Y. Patil School of Medicine, Navi Mumbai, Maharashtra, India. 3Assistant Professor, Department of Pathology, D.Y. Patil School of Medicine, Navi Mumbai, Maharashtra, India. 4Senior Resident, Department of Pathology, D.Y. Patil School of Medicine, Navi Mumbai, Maharashtra, India

Abstract

Background: Verruciform xanthoma is a rare benign lesion most commonly involving oral mucosa. Genital involvement is uncommon. Large scrotal verruciform xanthomas are particularly rare and may clinically mimic verrucous or papillomatous lesions. Chronic irritation and epithelial damage are considered possible contributing factors. Case Presentation: A 76-year-old male presented with a gradually enlarging scrotal mass clinically diagnosed as papilloma. Histopathological examination revealed hyperplastic squamous epithelium with papillomatosis and numerous foamy macrophages within fibrovascular cores, confirming verruciform xanthoma. Conclusion: The present case is noteworthy due to its relatively large size, scrotal location, and close clinical resemblance to papilloma, highlighting the indispensable role of histopathological examination in establishing the diagnosis to avoid diagnostic pitfalls and unnecessary aggressive management.

Keywords: Xanthoma, Foam cells.

Outline